Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors.
نویسندگان
چکیده
The severe acute respiratory syndrome (SARS) coronavirus 3CL protease is an attractive target for the development of anti-SARS drugs. In this paper, cinanserin (1) analogs were synthesized and tested for the inhibitory activities against SARS-coronavirus (CoV) 3CL protease by fluorescence resonance energy transfer (FRET) assay. Four analogs show significant activities, especially compound 26 with an IC(50) of 1.06 microM.
منابع مشابه
Characterization and Inhibition of the Main Protease of Severe Acute Respiratory Syndrome Coronavirus
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 56 10 شماره
صفحات -
تاریخ انتشار 2008